Rivaroxaban(S)-Rivaroxaban;BAY 59-7939;RivaroxabanIsomer;Rivaroxaban;
Rivaroxaban(S)-Rivaroxaban;BAY 59-7939;RivaroxabanIsomer;Rivaroxaban;
Isetyenziswe kwizigulane zabantu abadala abane-hip ekhethiweyo okanye utyando lokutshintshwa kwamadolo ukukhusela i-venous thrombosis (VTE).
Isetyenziselwa ukuthintela okanye ukunciphisa ukubunjwa kwe-thrombosis, i-thrombosis ye-vein deep (DVT) kunye ne-pulmonary embolism (PE) emva kokuhlinzwa kokutshintshwa kwe-hip okanye idolo.
Umthamo onconywayo ngumlomo we-rivaroxaban 10mg, kanye ngosuku.I-Rivaroxaban 10mg inokuthatyathwa ngokutya okanye yodwa.I-Rivaroxaban i-15mg okanye i-20mg iipilisi kufuneka ithathwe ngokutya.
umgangatho: usp40
IsiVavanyo: 99-102%
Umphandle: Umgubo omhlophe
Iphakheji: 25kg / igubu
Thatha i-4-(4-aminophenyl) i-morpholin-3-enye (SM-1), (S)-N-glycidyl phthalimide (SM-2), i-5-chlorothiophene-2- Formyl chloride (SM-3) yinto yokuqala .Emva kwe-condensation, i-cyclization, i-aminolysis kunye ne-acylation, i-rivaroxaban eluhlaza ifunyenwe, kwaye i-rivaroxaban egqityiweyo ihlanjululwe.
Ukulungiselela: Le mveliso yipilisi ebomvu efakwe kwifilimu.
Izincedisi:
Undoqo wecwecwe: i-microcrystalline cellulose, i-croscarmellose sodium, i-lactose monohydrate, i-hypromellose, i-sodium lauryl sulfate, i-magnesium stearate
Ukwaleka: i-polyethylene glycol, i-hypromellose, i-titanium dioxide, i-iron oxide ebomvu
I-Rivaroxaban yinto ekhethiweyo kakhulu, ichiza lomlomo elithintela ngokuthe ngqo i-factor Xa.Ngokuthintela okukhethiweyo kunye nokhuphiswano olukhululekileyo kunye nebophelelo lwe-Xa kunye nomsebenzi weprothrombin, yandisa ixesha lexesha le-thromboplastin (PT) kunye nexesha le-prothrombin (aPTT) ngendlela exhomekeke kwidosi, enokuphazamisa i-coagulation waterfall Indlela engapheliyo kunye ne-exogenous. inqanda ukuveliswa kwe-thrombin kunye ne-thrombosis.I-Rivaroxaban ayithinteli i-thrombin (i-activating factor Ⅱ), kwaye ayizange ibonakalise ukuba inefuthe kwiiplatelet.
Umahluko obalulekileyo phakathi kwe-rivaroxaban kunye ne-fondaparinux/heparin kukuba ayifuni ukuthatha inxaxheba kwe-antithrombin III kwaye inokuchasa ngokuthe ngqo i-free and bound factor Xa;ngelixa i-heparin idinga i-antithrombin III ukuba isebenze, kwaye ayinayo impembelelo kwi-factor Xa kwi-prothrombin complex.
JIN DUN Medical uyeIsiqinisekiso se-ISO kwaye sidibana nemigangatho yemveliso ye-GMP, kuqeshwe iingcali zasekhaya nezangaphandle zokwenziwa kweziyobisi ezinamava atyebileyo ukukhokela iR&D yenkampani.
I-TECHNOL OGY I-ADVANTAGES
●Uxinzelelo oluPhezulu lweCatalytic Hydrogenation.Uxinzelelo oluPhezulu lwe-Hydrogenolysis Reaction.I-Cryogenic Reaction (<-78%C)
● I-Aromatic Heterocyclic Synthesis
● Ukusabela ngokutsha
● IsiGqibo seChiral
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction
Izixhobo
ILebhu yethu inezixhobo ezahlukeneyo zovavanyo kunye novavanyo, ezifana ne: NMR (Bruker 400M) ,HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, iKhalorimitha yokuSkena okwahlukileyo (DSC), iMicroscope ye-Electron...
R&D Iqela
I-Jindun Medical ineqela labasebenzi abaqeqeshiweyo be-R&D, kwaye iqeshe iingcali ezininzi zokwenziwa kweziyobisi zasekhaya nezangaphandle ukukhokela i-R&D, ukwenza udibaniso lwethu luchaneke ngakumbi kwaye lusebenze kakuhle.
Siye sanceda iinkampani ezininzi eziphezulu zamachiza zasekhaya, ezifanaHansoh, Hengrui kunye ne-HEC Pharm.Apha siza kubonisa inxalenye yazo.
Customization Case One:
Inombolo yeCas: 110351-94-5
Ityala leSibini:
Inombolo yeCas: 144848-24-8
Customization Case Three:
Inombolo yeCas: 200636-54-0
1.Lungiselela abaPhakathi abatsha okanye ii-APIs.Ngokufanayo nokwabelana ngetyala elingasentla, abathengi baneemfuno ze-Intermediates ezithile okanye ii-APIs, kwaye abanakuzifumana iimveliso ezifunekayo kwimarike, ngoko sinokunceda ukwenza ngokwezifiso.
2.Ukuphuculwa kweNkqubo yeeMveliso eziDala.Iqela lethu liya kunceda ukukhulisa nokuphucula imveliso enjalo indlela yokusabela indala, ixabiso lemveliso liphezulu, kwaye ukusebenza kakuhle kuphantsi.Sinokubonelela ngamaxwebhu apheleleyo okuhanjiswa kwetekhnoloji kunye nokuphuculwa kwenkqubo, sincede umthengi kwimveliso esebenzayo.
Ukusuka ekujoliswe kuko ngamachiza ukuya kwi-INDs, iJIN DUN Medical ikubonelelaisitophu esinye sezisombululo ze-R&D ezenzelwe wena.
I-JIN DUN Medical igxininisa ekudaleni iqela elinamaphupha, ukwenza iimveliso ezinesidima, ubuqili, ubukhali, kwaye uphume konke ukuze ube liqabane elithembekileyo kunye nomhlobo wabathengi!
![iCasp ungin acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];](http://cdn.globalso.com/jindunchem-med/fbe17385-300x300.jpg)