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iCasp ungin acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];

iCasp ungin acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];

Inkcazelo emfutshane:


Iinkcukacha zeMveliso

Iithegi zeMveliso

Isicelo

ICaspofungin Acetate Biological Activity

Chaza I-Caspofungin Acetate sisiyobisi se-antifungal esingenakukhuphisana ngokuthintela ukuhlanganiswa kwe-1,3-β-d glucan synthase.
Eyeleleneyoiindidi indlela yomqondiso >> Anti-intsholongwane >> Umngundo

Iindawo zophando >> Yosulela

Kwi-vivouphando Iimpuku ezitofwe nge-caspofungin zazingenalo utshintsho olubalulekileyo kwi-waveform ye-ERG kwi-vitreous concentration ye-0.41 ukuya kwi-4.1 μM, kwaye i-retina yazo yayingenalo utshintsho olubonakalayo lwe-morphological okanye ukulahleka kweeseli.Kwi-concentration ye-vitreous ye-41 μM, i-caspofungin yanciphisa i-amplitude ye-wave, i-b wave kunye ne-scotopic threshold response ye-ERG, kwaye yabangela ukuhla kwenani leeseli kwi-cell ye-ganglion layer [1].I-Carprofungin (8 mg / kg) okanye i-amphotericin B 1 mg / kg, inaliti ye-intraperitoneal kanye ngosuku 30 h emva kokusuleleka kweentsuku ezi-7 ezilandelelanayo, ngokumalunga nokuphathwa kwemoto yokulawula, i-100% yokusinda ngosuku lwe-28, okubangelwa yi-100% izinga lokufa kwe-11 emini. , emva kocelomngeni olusulelayo.Xa kuthelekiswa nonyango lokulawula isithuthi ngosuku lwe-5, i-caspofungin yanciphisa ukubuyiswa kweCandida esebenzayo kwiintso kunye nezicubu zengqondo xa umthwalo wokulawula ufikelele kwincopho yayo.Iigundane eziphathwe nge-caspofungin kwi-dose ye-2 mg / kg okanye ngaphezulu zibe nomthwalo wengqondo ophantsi kakhulu ngosuku lwe-5 kuneempuku eziphathwa nge-amphotericin B. I-Amphotericin B kunye nonyango lwe-caspofungin lunciphisa umthwalo we-fungal we-renal nge-1.7 log CFU / g kunye ne-2.46 kwi-3.64 log CFU /g, ngokulandelanayo [2].
Isilwanyanaumfuniselo Unyango lwe-Antifungal lwaqalwa emva kweeyure ezingama-30 emva komngeni osulelekileyo kwaye lwanikezelwa ngenaliti ye-intraperitoneal (ip) kanye ngosuku ngeentsuku ze-7.Iigundane zaphathwa nge-1, i-2, i-4, okanye i-8 mg / kg / imini ye-caspofungin, i-1 mg / kg / imini ye-amphotericin B okanye ulawulo lwesithuthi (amanzi ahlambulukileyo adibeneyo).Ukusebenza komzekelo kwavavanywa ngeendlela ezintathu: ngokubeka iliso izinga lokusinda kwezilwanyana ze-10 kwiqela ngalinye lonyango, ngokubeka iliso umthwalo weCandida kwizintso kunye nezicubu zengqondo zeqela lesibini lezilwanyana eziphathwayo, kunye nokuvavanya i-histologically izintso.Kwaye ingqondo.Iqela lesithathu lezilwanyana eziphathwayo.Iigundane zixhaswe yi-CO 2 inhalation kwaye zikhuliswe kwiiyure ze-30 (ukulawulwa kwemoto kuphela) kunye nosuku lwe-5 (iiyure ezingama-24 emva kwe-4th dose), i-8 (iiyure ezingama-24 emva kwedosi yokugqibela), kunye ne-14, iiyure ze-21 kunye ne-histological. isampula yethishu.(Kuphela unyango lwe-caspofungin), kunye ne-28 emva kokuhlaselwa.
Iimbekiselo [1].Mojumder DK, et al.Ukuvavanya ityhefu ye-retinal ye-intravitreal caspofungin kwiliso lempuku.Tyala iOphthalmol Vis Sci.2010 Nov;51(11):5796-803.

[2].Flattery, uAmy M. et al.Ukusebenza kwe-caspofungin kwimodeli yemouse yabantwana be-central nervous system candidiasis.Iiarhente zeAntimicrobial kunye neChemotherapy (2011), 55 (7), 3491-3497.

Iimpawu zekhemikhali kunye nezomzimba ze-caspofungin acetate

Indawo yokubilisa 1408.1ºC ku-760 mmHg
Ifomula yemolekyuli I-C56H96N10O19
Ubunzima bemolekyuli 1093.31000
Umgangatho ochanekileyo 1092.64000
PSA 412.03000
LogP 0.06150
Iimpawu zenkangeleko mhlophe ukuya beige
Uxinzelelo lomphunga 0mmHg ku-25°C
Iimeko zokugcina 20°C
Ukunyibilika kwamanzi I-H2O: i-soluble15mg/mL (isisombululo esicacileyo)

Caspofungin Acetate Customs

Ikhowudi yeCustoms 2933990099
Chinese Overview 2933990099. Ezinye iikhompawundi ze-heterocyclic eziqukethe kuphela i-nitrogen heteroatoms.Ixabiso lerhafu eyongeziweyo: 17.0%.Izinga lesaphulelo serhafu: 13.0%.Imiqathango yolawulo: Akukho.Umrhumo wesizwe othandwa kakhulu: 6.5%.Uluhlu lweerhafu ngokubanzi: 20.0%
Iimpawu zesibhengezo Igama lemveliso, umxholo wezithako, ukusetyenziswa, i-hexamethylene chloride, nceda ubonise imbonakalo, i-6-caprolactam, nceda ubonise imbonakalo, umhla wokusayina
Isishwankathelo 2933990090. i-heterocyclic compounds kunye ne-nitrogen hetero-atom (s) kuphela.IVAT:17.0%.Ireyithi yesaphulelo serhafu:13.0%..Intlawulo yeMFN:6.5%.Uluhlu lweerhafu ngokubanzi: 20.0%

Inkqubo yeMveliso

I-Caspofungin kufuneka ilungiswe nge-fermentation semi-synthetic technology.Imveliso ekrwada yeringi ephambili kufuneka ifunyanwe ngeteknoloji yokubilisa, kwaye ke imveliso ephakathi ifunyenwe ngokwahlukana kunye nokusulungekiswa, kwaye ke imveliso ephakathi isetyenziswa njengesixhobo sokuqala ukugqiba ikhonkco lekhonkco elisecaleni usebenzisa itekhnoloji yokwenziwa ekugqibeleni into ekujoliswe kuyo.Ngenxa yokuba "i-fermented semi-synthetic" imveliso kufuneka ihambe ngeekhonkco ezininzi zobugcisa ezifana nokubilisa, ukwahlukana kunye nokuhlanjululwa, ukudibanisa, njl., indlela yobugcisa kunye nolawulo lwepharamitha yenkqubo inzima kakhulu kwi-Chemicalbook.Ukongezelela, iimfuno zokulawula ukubhaliswa kwe-caspofungin, imveliso ebilisiweyo ye-semi-synthetic, nayo iphezulu kakhulu.Amaxwebhu esicelo kufuneka aqale kumthombo wokuvubela, kungekuphela nje ngokucwangciswayo ukufunda ukulinywa kohlobo, itekhnoloji yokuvubela, kunye neteknoloji yokucoca, kodwa nokuphonononga inkqubo yokudibanisa.Indlela, iimeko, kunye nokulawulwa kokungcola kwinkqubo, ngenxa yokuba imveliso yokugqibela ibuthathaka, nakuphi na ukungakhathali kuya kucima yonke imizamo yangaphambili, kwaye ubunzima bobugcisa kunye neendleko azibalulekanga.

Kungenxa kanye ngenxa yemiqobo ephezulu yobugcisa kunye nomhlaba okhuphisanayo othe i-Hengrui Caspofungin igcine indawo yexabiso elungileyo emva koluhlu lwayo.

Ukhuseleko lwePatent luphelelwe ngo-2014
Ukuthengiswa kwenaliti ye-terminal caspofungin kumaziko onyango karhulumente eTshayina (iyunithi: ishumi lamawaka eyuan)

vqd

Ukuza kuthi ga ngoku, ngamachiza enziwe afana nalawo enziwe afana nalawo aveliswe ngumenzi eHengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals, kunye neHaisco avunyiweyo ukuba afakwe kuluhlu.Huadong Medicine?

Inkampani yokuqala yophando ye-caspofungin acetate yi-Merck, kwaye izicelo zoluhlu lweenkampani ze-6 ziphantsi koqwalaselo kwaye zivunyiwe, ezizezi, Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Sihuan Pharmaceutical, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, kunye neTian Weipharmaceutical Bio.

Uluhlu lweeMveliso ezidityanisiweyo

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Isatifikethi

JIN DUN Medical uyeIsiqinisekiso se-ISO kwaye sidibana nemigangatho yemveliso ye-GMP, kuqeshwe iingcali zasekhaya nezangaphandle zokwenziwa kweziyobisi ezinamava atyebileyo ukukhokela iR&D yenkampani.

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Izinto eziluncedo kwiMedical Customization

I-TECHNOL OGY I-ADVANTAGES
●Uxinzelelo oluPhezulu lweCatalytic Hydrogenation.Uxinzelelo oluPhezulu lwe-Hydrogenolysis Reaction.I-Cryogenic Reaction (<-78%C)
● I-Aromatic Heterocyclic Synthesis
● Ukusabela ngokutsha
● IsiGqibo seChiral
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction

I-JIN DUN R&D

Izixhobo

ILebhu yethu inezixhobo ezahlukeneyo zovavanyo kunye novavanyo, ezifana ne: NMR (Bruker 400M) ,HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, iKhalorimitha yokuSkena okwahlukileyo (DSC), iMicroscope ye-Electron...

R&D Iqela

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Ukwabelana ngetyala

Siye sanceda iinkampani ezininzi eziphezulu zamachiza zasekhaya, ezifanaHansoh, Hengrui kunye ne-HEC Pharm.Apha siza kubonisa inxalenye yazo.

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Customization Case One:

Inombolo yeCas: 110351-94-5

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Ityala leSibini:

Inombolo yeCas: 144848-24-8

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Customization Case Three:

Inombolo yeCas: 200636-54-0

Imo yeNtsebenziswano

1.Lungiselela abaPhakathi abatsha okanye ii-APIs.Ngokufanayo nokwabelana ngetyala elingasentla, abathengi baneemfuno ze-Intermediates ezithile okanye ii-APIs, kwaye abanakuzifumana iimveliso ezifunekayo kwimarike, ngoko sinokunceda ukwenza ngokwezifiso.

2.Ukuphuculwa kweNkqubo yeeMveliso eziDala.Iqela lethu liya kunceda ukukhulisa nokuphucula imveliso enjalo indlela yokusabela indala, ixabiso lemveliso liphezulu, kwaye ukusebenza kakuhle kuphantsi.Sinokubonelela ngamaxwebhu apheleleyo okuhanjiswa kwetekhnoloji kunye nokuphuculwa kwenkqubo, sincede umthengi kwimveliso esebenzayo.

Ukusuka ekujoliswe kuko ngamachiza ukuya kwi-INDs, iJIN DUN Medical ikubonelelaisitophu esinye sezisombululo ze-R&D ezenzelwe wena.

I-JIN DUN Medical igxininisa ekudaleni iqela elinamaphupha, ukwenza iimveliso ezinesidima, ubuqili, ubukhali, kwaye uphume konke ukuze ube liqabane elithembekileyo kunye nomhlobo wabathengi!


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