2-butyl-5-nitro-3-benzofuranyl) [4-[3-(dibutylaMino) propoxy]phenyl]

Isetyenziswa ngokweklinikhi kwi-hyperuricemia ephambili kunye neyesibini, ngakumbi kwizigulane ezine-hyperuricemia, kunye nezigulane ezinokungaphumeleli kwezintso, kunye nezigulane ezine-gout ephindaphindiweyo okanye engapheliyo, kunye nezigulane ezine-Hyperuricemia.Isetyenziswe kwizigulane ezine-Gouty nephropathy ukukhulula iimpawu kunye nokunciphisa ukubunjwa kwamatye e-uric acid ezintso;amatye e-gout;isetyenziswa kwi-uric acid kwizintso zamatye kunye nesifo sezintso ze-uric acid.

Ichiza elitsha lokuchasana ne-arrhythmic i-Atrial fibrillation (AF) sisifo esinokubeka ubomi esichengeni.Ngenxa yokuguga kwabemi, iziganeko zehlabathi kunye nokufa kwe-fibrillation ye-atrial ziyanda, kwaye ibe yingxaki entsha yeMpilo yoluntu.Kukho i-2.5 yezigidi zezigulane ezine-atrial fibrillation e-United States kunye ne-4.5 yezigidi kwi-European Union.Ngokwezibalo, ukuxhaphaka kwe-fibrillation ye-atrial phakathi kwabantu abangaphezu kweminyaka engama-30 ubudala kwilizwe lam ngu-0.77%, okwandayo kunye nobudala, kwaye amadoda aphezulu kunabasetyhini (0.9%: 0.7%).Izifo ezibangela i-atrial fibrillation ngokuyintloko ziquka uxinezeleko lwegazi, isifo sentliziyo, isifo sentliziyo esibizwa ngokuba yivalvular heart disease, i-spontaneous dilated cardiomyopathy, kunye nokusilela kwentliziyo.Uphawu oluphambili lwezigulane ezine-fibrillation ye-atrial yizinga elingaqhelekanga le-ventricular, kwaye ukulawula izinga lentliziyo kuthatha indawo ethile kunyango olunzima kunye nokugcinwa kweempawu.I-Amiodarone idlala indima enhle ekulawuleni izinga lentliziyo kunye nokubuyisela isigqi se-sinus, kodwa imiphumo emibi yezitho ezijoliswe kuyo ezinxulumene necandelo le-iodine kwisakhiwo sayo kunciphisa ukusetyenziswa kwayo kweklinikhi, njengomonakalo kwimiphunga, i-thyroid kunye nesibindi.Ezi mpendulo zikhankanywe ngasentla kunye nesakhiwo sayo Iodine inxulumene ngokusondeleyo.Iyeza elitsha le-antiarrhythmic iDronedarone (i-Dronedarone) yafunyanwa ngokuguqula isakhiwo se-amiodarone.I-Dronedarone ineempawu ze-electrophysiological ezifana ne-amiodarone, kodwa ayinayo iodine kwisakhiwo sayo, ngoko inokuphepha iziphumo ezibi kakhulu ze-cardiac ezibangelwa yi-iodine Chemicalbook.I-Dronedarone yavunywa ukuthengiswa yi-US Food and Drug Administration (FDA) ngoJulayi 2009, kwaye yavunywa ukuthengiswa kwi-European Union kwi-2009. Kwakhona iyeza lokuqala elitsha le-antiarrhythmic elivunyiweyo kwi-European Union kwiminyaka eyi-10.I-Dronedarone yi-N-[2-butyl-3-[4-[3- (dibutylamino)) propoxy] -5-benzofuranyl]-methanesulfonamide, oko kukunciphisa i-benzofuran derivative efunyenwe ngokuguqulwa kwesakhiwo se-amiodarone, engekho ukusabela kakubi kwentliziyo.Isusa i-athomu ye-iodine kwi-amiodarone ukunciphisa ubuthi be-thyroid kunye nezinye izitho;yongeza iqela le-methylsulfonyl kwicala le-benzofuran ukunciphisa i-lipophilicity, ngaloo ndlela inciphisa isiqingatha sobomi bechiza kunye nokunciphisa isiphumo sokuqokelelwa kwezicubu kunye nokuba nokwenzeka kwechiza le-neurotoxicity.Bobabini i-2011 ye-US version kunye ne-2010 ye-European version ye-Atrial Fibrillation Guidelines incoma i-dronedarone yonyango lwe-fibrillation ye-atrial.I-Dronedarone ikhuselekile kwaye iyasebenza ekuphatheni izinga le-ventricular kunye nokugcina izinga le-sinus kwizigulane ezahlukeneyo ngaphandle kwe-AF enzima.Inokuba liyeza elisebenzayo lokuthatha indawo ye-amiodarone.I-Dronedarone inokunciphisa ukusweleka kwezigulane ezine-AF kunye nezigulana ezizingisileyo ze-AF.Ke ngoko, kulindeleke ukuba ibe liyeza lokuqala kwizigulana ze-AF ngaphandle kokusilela kwentliziyo okumandla.Ngaphezu koko, ukusetyenziswa kwe-anticoagulants kwizigulane ezinobungozi obuphakathi kwe-AF kunenzuzo ekusebenziseni i-dronedarone.