Ukwenzela ukuqhubela phambili ukukhuthaza ukuthandwa kwesayensi yokuthintela umhlaza womlomo wesibeleko kubasetyhini abakwiminyaka elungileyo kunye nokuphucula inqanaba lezempilo labasetyhini, umboniso wokuqala wokuthintela umhlaza womlomo wesibeleko ngomxholo othi "impilo entle, iklasi elungileyo yebhotwe, indima ephambili yokuthandwa kwesayensi. ” yavulwa eBeijing.U-Tan Xianjie, ugqirha oyintloko we-gynecology kunye nokubeleka kwisibhedlele saseBeijing Union Medical College, uZou Shien, ugqirha oyintloko we-gynecology kunye ne-obstetrics ye-Fudan University Affiliated Hospital ye-Gynecology and Obstetrics, kunye no-Chen Qiuping, intloko yesebe lokunakekelwa kwezempilo kwiZiko leNkonzo yezeMpilo yoLuntu yaseLiulitun. , ISithili saseChaoyang, eBeijing, wathatha iqonga lokwazisa ulwazi lwesifo somhlaza womlomo wesibeleko kunye nothintelo kuluntu ngendlela entsha kunye namagama ahlekisayo, ukunceda ukukhawulezisa ukupheliswa komhlaza womlomo wesibeleko.
Izinga lezehlo zomhlaza womlomo wesibeleko liyenyuka, libonisa umkhwa omncinci
Umhlaza womlomo wesibeleko lithumba elibi eliqhelekileyo labasetyhini.Ngo-2020, kuya kubakho malunga ne-604000 yezehlo ezitsha zomhlaza womlomo wesibeleko kunye nama-342000 aswelekayo kwihlabathi liphela.Ngo-2020, kukho malunga ne-110000 yezehlo ezitsha zomhlaza womlomo wesibeleko e-China, kwaye inani lokufa limalunga ne-59000, libalelwa kwi-18% yeemeko zehlabathi zomhlaza womlomo wesibeleko kunye ne-17% yabantu ababhubhileyo ngenxa yomhlaza womlomo wesibeleko.Njengoko uphuhliso lwezoqoqosho nentlalo yaseTshayina, ushishino kunye nokufudukela ezidolophini kuqhubeka ngesantya, kunye nokusingqongileyo ephilayo kunye nendlela yokuphila abahlali ukutshintsha ngokukhawuleza, izinga leziganeko zomhlaza wesibeleko uyaqhubeka ukwanda, ebonisa umkhwa wolutsha, kwaye umyinge weminyaka uyaqhubeka nokuhla.
Ngo-2020, uMbutho wezeMpilo weHlabathi wabhengeza iQhinga leHlabathi lokuKhawulezisa ukupheliswa komhlaza womlomo wesibeleko.Kwiminyaka yakutshanje, i-China incamathele ukubaluleka okukhulu kwimpilo yabasetyhini kwaye iphumeze ngenkuthalo imigaqo-nkqubo eyahlukeneyo yokuthintela umhlaza womlomo wesibeleko kunye neentshukumo eziphambili.NgoJanuwari 2023, iKomishoni yezeMpilo yeSizwe kunye namanye amasebe ayi-10 akhuphe iSaziso sokuShicilela kunye nokusasaza iSicwangciso sokuSebenza sokuKhawuleza ukupheliswa koMhlaza wesibeleko (2023-2030), echaza ngokucacileyo ukuba ngo-2030, umsebenzi wokulinga wogonyo lweHPV amantombazana asahamba isikolo aza kuqhubeka ekhuthazwa;Izinga lokujongwa komhlaza womlomo wesibeleko kwabasetyhini abakwiminyaka yokuhamba bafikelele kuma-70%;Izinga lonyango lomhlaza womlomo wesibeleko kunye nezilonda ezinobungozi zifikelele kwi-90%.
UTan Xianjie wabonisa ukuba nangona umhlaza womlomo wesibeleko uyingozi, kukho amathuba amathathu okuthintela, oko kukuthi, uthintelo olunamanqanaba amathathu, oko kukuthi, uthintelo oluphambili lokunciphisa usulelo lwe-HPV ngogonyo logonyo lwe-HPV kunye nendlela yokuphila esempilweni, uthintelo lwesibini ukuya kwangexesha. ukubona kwaye ujongane nezilonda ezinobungozi ngokujonga umhlaza womlomo wesibeleko, kunye nothintelo lwenqanaba lesithathu ukwenza utyando kunye neradiotherapy yomhlaza womlomo wesibeleko oqinisekisiweyo.
Tofa ngokukhawuleza, musa ukubambelela kwisitofu sokugonya se-HPV samaxabiso aphezulu
I-China lilizwe elinelona nani likhulu lezitofu ezivunyiweyo ze-HPV kwihlabathi.Zintlanu izitofu ze-HPV zabasetyhini ababudala buphakathi kwe-9 ukuya kuma-45 ubudala, kubandakanywa isitofu sokugonya se-HPV esiphuma kumazwe angaphandle, isitofu sokugonya se-HPV esine-valent ezine, isitofu sokugonya se-HPV esine-valent ezimbini kunye nezitofu ezimbini ze-HPV zasekhaya.Izibalo zibonisa ukuba ukusuka kwi-2018 ukuya kwi-2020, inani lokugonywa kwe-HPV e-China liye landa unyaka nonyaka, ukusuka kwi-3.417 yezigidigidi zeedosi kwi-2018 ukuya kwi-12.279 yezigidi zeedosi kwi-2020, kodwa izinga lokugonywa lisafuna ukuphuculwa.
UZou Shien uthe abanye abahlobo basetyhini banyanzelise ukuba balinde isitofu sokugonya se-HPV samaxabiso aphezulu endaweni yogonyo, ngoko baye baphoswa “lixesha legolide” lokuthintela umhlaza womlomo wesibeleko.Kufuneka sikuphephe ngokumfamekileyo ukulinda izitofu ze-HPV zamaxabiso aphezulu, ezingayi kuba nexabiso lelahleko ukuba sosuleleke kwinkqubo yokulinda.Kufuneka sikhuthaze uluntu ukuba lubambelele kumgaqo "wogonyo lwangethuba kunye nokhuseleko lwangethuba", kwaye bakhethe ngokuguquguqukayo ngokwezibonelelo zokugonya kunye neemeko zabo zoqoqosho.
E-China, ngaphezu kwe-84.5% yeemeko ze-cervical squamous cell carcinoma zidibene ne-HPV yohlobo lwe-16 kunye ne-18 yosulelo.Ngokuphathelele kulo mba, uZou Shien wachaza ukuba i-HPV16 kunye ne-HPV18 zezona ntlobo zibalulekileyo ze-HPV yomngcipheko ophezulu, kwaye i-bivalent, i-four-valent kunye ne-nine-valent vaccines ye-HPV inokugqunywa.Ugonyo logonyo lwe-HPV olune-bivalent lunokuthintela uninzi lomhlaza womlomo wesibeleko kunye nezilonda ezingaphambi komhlaza, kwaye uthintelo lomhlaza "lwanele".Nokuba leliphi ixabiso lesitofu sokugonya, ugonyo lwakwangoko “luxabisekile”.
Ukukhawulezisa ugonyo usemncinci kwaye uphucule inqanaba lokuqala lothintelo kunye nokhuseleko lomhlaza womlomo wesibeleko
“Njengomgcini-sango” wempilo yabahlali, iziko lenkonzo yezempilo eluntwini lidlala indima ebalulekileyo ekuthinteleni umhlaza womlomo wesibeleko kwinqanaba elisezantsi.Ngokwenza imisebenzi efana nesayensi yomhlaza womlomo wesibeleko kunye nogonyo logonyo lwe-HPV, isasaza ulwazi lwenzululwazi, oluchanekileyo nolusebenzayo lomhlaza womlomo wesibeleko kwaye iphucula izinga lokugonywa kwesitofu sokugonya se-HPV.Kwangaxeshanye, ukubonelela ngeenkonzo zokugonya i-HPV kubasetyhini abakwiminyaka yobudala yokuya esikolweni ikwangomnye wemisebenzi ebalulekileyo yesebe lokhathalelo lwempilo kwiziko lenkonzo yezempilo yoluntu.
U-Chen Qiuping ubonise ukuba okwangoku, amaziko eenkonzo zempilo yoluntu angakwazi ukugonya amayeza e-HPV avela kumazwe angaphandle nasekhaya;Ngexesha elifanayo kwizifo zesayensi ezidumileyo, ngoncedo lweqonga logcino lwe-intanethi, abantu abaninzi abafuna ukugonywa ngogonyo lwe-HPV baya kunikwa umjelo wogcino okhawulezayo.Ukunceda ukukhawulezisa ukupheliswa komhlaza womlomo wesibeleko ngokuqhubeka nokuphucula iinkonzo zogonyo lwe-HPV."Sikwakhumbuze abasetyhini kwiminyaka eyiyo ukuba banciphise ukuthandabuza kwabo okunxulumene nogonyo kwaye banqande ukuphoswa elona xesha lilungileyo lokugonya ngenxa yokuqhubeka belinda amaxabiso aphezulu amayeza okugonya i-HPV."
Okwangoku, izehlo zomhlaza womlomo wesibeleko ziya zibancinci, kwaye uninzi lwabasetyhini sele luqalisile ukuzisa abantwana babo ukuba badibane malunga nogonyo lwe-HPV.Ukuphendula, u-Chen Qiuping uthe uxwebhu lwesikhundla kwisitofu sokugonya se-HPV olukhutshwe nguMbutho wezeMpilo weHlabathi lugxininise ukuba abantu ekujoliswe kubo ngogonyo lwe-HPV yayingamantombazana aneminyaka eyi-9 ukuya kwi-14 leminyaka ubudala, kwaye iidosi ezimbini zesitofu sokugonya se-HPV ziye zacetyiswa.Le ndlela yokugonya iyonga kakhulu kwaye ifanelekile, nto leyo ibaluleke kakhulu ekuphuculeni ukufikeleleka kogonyo kunye nenqanaba lokugonya.
Ukuthintelwa komhlaza womlomo wesibeleko akufuneki kube “kukudubula okukodwa”, kodwa kufuneka kubambelele ekuhlolweni rhoqo
Emva kothintelo oluphambili ngogonyo lwe-HPV, ludityaniswe nokujongwa rhoqo komhlaza womlomo wesibeleko kuthintelo lwesibini, kukwabalulekile ukuthintela izilonda zomhlaza womlomo wesibeleko kumabakala angaphambi komhlaza kunye nakwangoko.Umhlaza womlomo wesibeleko unokujongwa ngovavanyo lwe-HPV yomlomo wesibeleko kunye novavanyo lwe-TCT (uvavanyo lweseli olusekwe kulwelo olucekethekileyo).Ukuze kubonwe izilonda ezinomhlaza womlomo wesibeleko kunye nomhlaza womlomo wesibeleko ngokukhawuleza, iingcali zicebisa ukuba abasetyhini abangaphezu kweminyaka engama-25 ubudala ababelana ngesondo kufuneka bahlolwe rhoqo.Bangaya kwisebe lomlomo wesibeleko, isebe le-gynecology okanye isebe lezempilo labasetyhini esibhedlele kwaye baphuhlise isicwangciso sokuhlola ngokweengcebiso zogqirha.
UTan Xianjie uthe uthintelo lomhlaza womlomo wesibeleko akufuneki lube “ludubulo olunye”.Abasetyhini abakubudala obufanelekileyo ababelana ngesondo nabo kufuneka benze uvavanyo lomhlaza womlomo wesibeleko emva kokugqiba ugonyo lwe-HPV.Ngokubanzi, kuyacetyiswa ukuba ujonge kanye emva kweminyaka emibini kwaye uhlengahlengise ubungakanani ngokweziphumo zovavanyo lokuqala.Ukufunyaniswa kwangoko kunye nokunyangwa komhlaza womlomo wesibeleko kunokunceda izigulane ukuba zisisuse esi sifo ngokukhawuleza kwaye zehlise ukubhubha komhlaza womlomo wesibeleko.UZou Shien uphinde wacebisa ukuba akukho mfuneko yokoyika xa usulelo lwe-HPV okanye izilonda zomlomo wesibeleko zifunyenwe, vele uye kwiziko lezonyango eliqhelekileyo.Nokuba wosulelwe yi-HPV okanye hayi, umhlaza womlomo wesibeleko unokuthintelwa ngogonyo lwe-HPV oludityaniswe nokuhlolwa komhlaza womlomo wesibeleko.
JinDun Medicalinentsebenziswano yexesha elide yophando lwezenzululwazi kunye neteknoloji yokuxhunyelelwa kwiiyunivesithi zaseTshayina.Ngezixhobo zonyango ezityebileyo zikaJiangsu, inobudlelwane bexesha elide kunye neIndiya, iSoutheast Asia, iSouth Korea, iJapan kunye nezinye iimarike.Ikwabonelela ngeenkonzo zentengiso kunye nentengiso kuyo yonke inkqubo ukusuka phakathi ukuya kwimveliso egqityiweyo ye-API.Sebenzisa izibonelelo eziqokelelweyo zeYangshi Chemical kwichemistry fluorine ukubonelela ngeenkonzo ezizodwa zokwenza imichiza kumaqabane.Ukubonelela ngenkqubo yokuveliswa kwezinto ezintsha kunye neenkonzo zophando lokungcola kubathengi abajoliswe kuyo.
I-JinDun Medical igxininisa ekudaleni iqela elinamaphupha, ukwenza iimveliso ngesidima, ubuqili, ubukhali, kwaye uphume wonke ube liqabane elithembekileyo kunye nomhlobo wabathengi! Ababoneleli besisombululo esisodwa, i-R&D elungiselelweyo kunye neenkonzo zemveliso ezilungiselelwe abaphakathi bamayeza kunye nee-APIs, yobuchwepheshaimveliso yamayeza elungiselelweyo(CMO) kunye nababoneleli ngeenkonzo zeR&D kunye nemveliso (CDMO).
Ixesha lokuposa: May-17-2023