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Isimbo saseYurophu se-3′-Hydroxy-3-Biphenylcarboxylic Acid Citric Acid 77-92-9

Isimbo saseYurophu se-3′-Hydroxy-3-Biphenylcarboxylic Acid Citric Acid 77-92-9

Inkcazelo emfutshane:

CAS no: 376591-95-6

Iipropati zeMichiza:Ii-Elthrombopag Intermediates


Iinkcukacha zeMveliso

Iithegi zeMveliso

Umgangatho WokuQala, kwaye uMthengi oPhakamileyo sisikhokelo sethu sokuhambisa olona ncedo lulungileyo kubathengi bethu. Kwezi ntsuku, besizama kangangoko ukuba phakathi kwabathumeli ngaphandle abafanelekileyo ngaphakathi kwintsimi yethu ukuzalisekisa abathengi abangakumbi abaya kuyidinga kwisitayile saseYurophu kwi-3′- IHydroxy-3-Biphenylcarboxylic Acid Citric Acid 77-92-9, Ngokungaphezulu kweminyaka eyi-8 yamashishini amancinci, ngoku siye saqokelela amava atyebileyo kunye nobuchwepheshe obuphambili ngexesha lokwenziwa kweemveliso zethu.
Umgangatho Wokuqala, kwaye uMthengi oPhakamileyo sisikhokelo sethu sokuzisa olona ncedo lulungileyo kubathengi bethu. Kwezi ntsuku, besizama kangangoko ukuba phakathi kwabo bathengisa ngaphandle abafanelekileyo ngaphakathi kwintsimi yethu ukuzalisekisa abathengi abangakumbi abaya kuyidingaChina 77-92-9 kunye CAS 77-92-9, Ngokusekwe kumgca wethu wokuvelisa ngokuzenzekelayo, ishaneli yokuthenga izinto eziphathekayo kunye neenkqubo zekontrakthi ezikhawulezayo zakhiwe kwilizwe laseTshayina ukuhlangabezana neemfuno ezibanzi neziphezulu zomthengi kwiminyaka yakutshanje.Besijonge phambili ekusebenzisaneni nabathengi abaninzi kwihlabathi liphela ukuze kuphuhliswe ngokufanayo kunye nokuxhamla!Ukugcina ukunyaniseka, ukwenza izinto ezintsha kunye nokusebenza kakuhle, silindele ngokunyanisekileyo ukuba singamaqabane oshishino ukudala ikamva lethu eliqaqambileyo!

I-2'-hydroxy-3'-nitro-3-biphenylcarboxylic acid isetyenziswe njengendawo ephakathi kwe-Eltrombopag.
I-Eltrombopag, ephuhliswe yi-GlaxoSmithKline (GSK) e-UK kwaye kamva iphuhliswe ngokudibeneyo kunye ne-Novartis eSwitzerland, yeyokuqala kwaye ivunyiwe kuphela i-molecule encinci ye-non peptide TPO receptor agonist emhlabeni.I-Eltrombopag yavunywa yi-US FDA kwi-2008 yonyango lwe-idiopathic thrombocytopenic purpura (ITP), kunye ne-2014 yonyango lwe-anemia ye-aplastic enzima (AA).Ikwalichiza lokuqala elavunywa yi-US FDA kunyango lwe-AA kwiminyaka engama-30 yakutsha nje.
NgoDisemba 2012, i-US FDA ivume i-Eltrombopag yonyango lwe-thrombocytopenia kwizigulane ezine-hepatitis C engapheliyo (CHC), ukwenzela ukuba izigulane ze-hepatitis C ezine-prognosis embi ngenxa yokubala kweplatelet ephantsi inokuqala kwaye igcine unyango oluqhelekileyo lwe-interferon kwizifo zesibindi.NgoFebruwari3, 2014, i-GlaxoSmithKline yabhengeza ukuba i-FDA inike isiqinisekiso sonyango lwe-Eltrombopag kunyango lwe-hemopenia kwizigulane ezine-chemicalbook aplastic anemia (SAA) ezinzima ezingazange ziphendule ngokupheleleyo kwi-immunotherapy.Ngo-Agasti 24, i-2015, i-US FDA ivume i-Eltrombopag yonyango lwe-thrombocytopenia kubantu abadala kunye nabantwana abaneminyaka eyi-1 kunye nangaphezulu kunye ne-immune immune thrombocytopenia (ITP) abangenayo impendulo eyaneleyo kwi-corticosteroids, i-immunoglobulins okanye i-splenectomy.NgoJanuwari4, 2018, i-Eltrombopag yavunywa ukuba ibhalwe e-China kunyango lwe-immune immune thrombocytopenia (ITP).

Umgangatho WokuQala, kwaye uMthengi oPhakamileyo sisikhokelo sethu sokuhambisa olona ncedo lulungileyo kubathengi bethu. Kwezi ntsuku, besizama kangangoko ukuba phakathi kwabathumeli ngaphandle abafanelekileyo ngaphakathi kwintsimi yethu ukuzalisekisa abathengi abangakumbi abaya kuyidinga kwisitayile saseYurophu kwi-3′- IHydroxy-3-Biphenylcarboxylic Acid Citric Acid 77-92-9, Ngokungaphezulu kweminyaka eyi-8 yamashishini amancinci, ngoku siye saqokelela amava atyebileyo kunye nobuchwepheshe obuphambili ngexesha lokwenziwa kweemveliso zethu.
Isimbo saseYurophu seChina 77-92-9 kunye CAS 77-92-9, Ngokusekwe kumgca wethu wokuvelisa ngokuzenzekelayo, ishaneli yokuthenga izinto eziphathekayo kunye neenkqubo zekontrakthi ezikhawulezayo zakhiwe kwilizwe laseTshayina ukuhlangabezana neemfuno ezibanzi neziphezulu zomthengi kwiminyaka yakutshanje.Besijonge phambili ekusebenzisaneni nabathengi abaninzi kwihlabathi liphela ukuze kuphuhliswe ngokufanayo kunye nokuxhamla!Ukugcina ukunyaniseka, ukwenza izinto ezintsha kunye nokusebenza kakuhle, silindele ngokunyanisekileyo ukuba singamaqabane oshishino ukudala ikamva lethu eliqaqambileyo!


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