4-Methoxybenzylalkohol;ANISALKOHOL;4-methoxy-benzenemethano;

Phakathi kwi-Moxonidine
Inokuvuyisa i-receptors ephakathi kwe-α2 kwaye ibangele imiphumo ye-antihypertensive, efana ne-clonidine.Izinga lokufunxa ngomlomo (90%) kunye ne-bioavailability (88%) zombini ziphezulu, kwaye akukho siphumo sokuqala sokupasa.Incopho yoxinaniso lwegazi lubonakala kwiiyure ezi-1 ukuya kwezi-3 emva kokuthatha ichiza.Uninzi lwalo lukhutshwa zizintso.I-t1/2 imalunga neeyure ezi-2.Ekliniki isetyenziselwa uxinzelelo lwegazi.

Ulwelo olungenambala okanye olutyheli kancinane.Iqondo lokunyibilika liyi-23-25.5 ° C, indawo yokubilisa yi-159 ° C, ubuninzi be-1.113 (15/15 ° C), kunye ne-refractive index yi-1.5442.Inyibilika lula etywaleni nakwi-ether, phantse ayinyibiliki emanzini.

Le mveliso inevumba elimnandi lefennel kwaye isoloko isetyenziselwa ukulungiswa kwejasmine, i-lilac kunye nezinye iziqholo, kwaye ifanelekile ukulungiselela iziqholo.Le mveliso sisiqholo esityiwayo esivunyelwe yi-GB2760-86 yelizwe lam.Isetyenziswa kakhulu ekulungiseni incasa ezifana nevanilla, itshokolethi, ikokoko, ialmond kunye nepesika.Ikwasetyenziswa kwi-organic synthesis nanjenge-solvent.

Ngokunciphisa i-anisaldehyde.I-Cannizzaro isabela kunye ne-anise, i-formaldehyde kunye ne-sodium hydroxide kwi-ethanol ukuvelisa i-p-methoxybenzyl alcohol.

Emva kokuba i-ethanol ifunyenwe nge-distillation, i-oyile efunyenwe yi-reaction itsalwa nge-benzene, i-acidified ngokufaka i-acetic acid, kwaye ingathathi hlangothi nge-sodium bicarbonate kwi-alkaline ebuthathaka.Emva kokuhlanjwa ngamanzi ukungathathi hlangothi, ibenzene ibuyiswa ngedistillation, kwaye intsalela iphantsi kwevacuum distillation ukuze ifumane i-p-methoxy Benzyl alcohol.

Isebenza ngokuvuselela i-presynaptic central α2-receptors.Impembelelo yayo ye-antihypertensive ifana ne-calcium antagonist nifedipine kunye ne-ACE inhibitor captopril.Isetyenziselwa uxinzelelo lwegazi oluyimfuneko.