I-3-Amino-4-pyrazole carbosamide hemisulfate

Iphakathi kwi-synthesis ye-allopurinol.

Ngomnye we-3-amino-4-substituted pyrazole series.Ingasetyenziswa njengendawo ephakathi ukudibanisa iikhompawundi ezininzi ze-pharmacologically ezisebenzayo ze-organic, ezifana ne-allopurinol, enye ye-pyrazolopyrimidine derivatives series, le yokugqibela ukususela ngo-1963 Ukususela ekusetyenzisweni kwayo kwezonyango, iye yaba iyeza eliphambili lokunyanga i-gout.Okwangoku, zimbalwa iindlela ezaziwayo zokudibanisa

I-3-aminopyrazole-4-carboxamide hemisulfate e-China, ngokukodwa ngokuphendula i-malononitrile kunye ne-triethyl orthoformate ukulungiselela i-ethoxymethylene malononitrile, kwaye emva koko kunye ne-Reactivity ye-hydrazine hydrate ivelisa i-3-amino-4-cyanopyrazole, ekugqibeleni isabela nge-asidi egxininisiweyo yokuvelisa i-sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), isivuno siphelele i-synthesis ngale ndlela malunga ne-60% (ibalwa njenge-malononitrile), le ndlela Ibandakanya ukuphendulwa kwamanyathelo amathathu, amanyathelo amade, kunye ne-reagents esetyenzisiweyo, njenge-malononitrile kunye ne-ethoxymethylene malononitrile, inetyhefu kwaye iyabiza.Ukongezelela, i-3-aminopyrazole-4 elungiselelwe yile ndlela -I-Formamide hemisulfate inombala onzima ukuwususa kwaye ufuna ukuqhutyelwa okongezelelweyo, okunzima kakhulu.

Kukho iingxelo kwiincwadi zangaphandle zisebenzisa i-pyridylamide hydrazone kunye ne-ethoxymethylene malononitrile njengezinto ezibonakalayo zokufumana i-3-amino-4-cyanopyrazole ngokudibanisa kunye ne-cyclization, kwaye emva koko uphendule nge-acid egxininisiweyo ye-sulfuric ukufumana i-compound ekujoliswe kuyo (Reuken G Jones. i-activemethylene compounds [J] J Am Chem Soc. 1952,74 (5): 4889 4891).Izinto eziphambili ezisetyenziswa kule ndlela ziyabiza, isivuno sokusabela asiphezulu, kwaye inzuzo yemveliso yoshishino iphantsi.Kumele ukuba kunzima.