3-(1-(Dimethylamino)ethyl]phenol

I-3-(1-(Dimethylamino) ethyl]phenol isetyenziswa njengendawo ephakathi yeRivastigmine tartrate.
I-rivastigmine tartrate yi-rivastigmine i-Alzheimer's disease drug, i-rivastigmine yi-physostigmine derivative yi-Novartis okokuqala iphuhliswe ngempumelelo igama lorhwebo i-Exelon (exelon), i-molecule enesakhiwo se-carbamate, luhlobo lwe-amino acid ye-cerebral cholinesterase inhibitor ekhethiweyo, inokunqanda. i-acetylcholinesterase kunye ne-butyrylcholinesterase, i-cholinergic neurons ngokulibazisa ukukhululwa kwe-acetylcholine degradation kunye namandla okukhuthaza i-cholinergic nerve conduction, inokuphucula ukuphazamiseka komsebenzi wokuqonda okuxutyushwa yi-cholinergic, ngaloo ndlela iphucula umsebenzi wokuqonda wezigulane ze-Alzheimer's disease.I-Rivastigmine i-protein ye-plasma yokubopha ibuthathaka, ngokulula ngokusebenzisa umqobo wegazi-ingqondo, enezinga eliphezulu lokukhetha kwengqondo.Ayisebenzi nje ngokukhethayo kweyona cortex yecerebral echaphazeleka lula kunye nehippocampus, kodwa ikwanqanda ngokukhethekileyo uhlobo olusezantsi lwe-AChE ebuchosheni, okukhokelela ekunciphiseni ukusebenza kweziphumo ebezingalindelekanga ze-peripheral cholinergic.I-Rivastigmine kwi-vivo-half-life ifutshane kunye nexesha elide lesenzo.Ngokungafaniyo ne-tacrine, le mveliso kwi-hippocampus kunye ne-cortex ye-G1 enzyme inhibitory effect yomelele.Ikliniki yonyango lwesifo sengqondo esixhalabisayo esiphakathi ukuya kwesasiphakathi se-Alzheimer, okanye isifo sika-Alzheimer sinokukrokrelwa ukuba sisifo sika-Alzheimer ngokwezonyango.