2-deoxy-2,2-difluoro-d-ribofuranose-3,5-dib enzoate

I-2-deoxy-2,2-difluoro-d-ribofuranose-3,5-dib enzoate isetyenziswe njengendawo ephakathi kweGemcitabine.
I-Gemcitabine yi-pyrimidine nucleotide analogue, eyeyamachiza okulwa nomhlaza we-metabolic.Inokuthintela inkqubela phambili ye-DNA synthesis kwixesha elithile, oko kukuthi, isigaba se-S.Ineempawu ze-anticancer spectrum ebanzi, indlela eyodwa yokusebenza, ubutyhefu obuphantsi, akukho ukumelana nokuphambana namanye amachiza e-chemotherapeutic kwaye akukho ndawo yetyhefu.Namhlanje, i-gemcitabine ivunyiwe ukuba isetyenziswe kumazwe angaphezu kwama-90, ibe liyeza lokuqala lokunyanga umhlaza wemiphunga weseli ongeyonxalenye encinci kunye "nomgangatho wegolide" wonyango lomhlaza we-pancreatic.