I-2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

I-2-bromo-2- (2-fluorophenyl) -1-cyclopropylethanone isetyenziswe njengendawo ephakathi yePrasugrel.
I-Prasugrel yi-thiophenopyridine antiplatelet eyenziwe ngu-Eli Lilly kunye ne-daiichisankyo, umenzi weyeza waseJapan.Lichiza elandulelayo.Yenza i-molecule esebenzayo emva kwe-metabolism ngokusebenzisa i-cytochrome P450 esibindi kwaye idibanisa ne-platelet P2Y12 receptor ukwenza i-active against platelet aggregation.Izifundo zeklinikhi zibonakalise ukuba i-60 mg yedosi inefuthe elingcono le-anticoagulant kune-300 mg yedosi eqhelekileyo kunye ne-600 mg yonyuso lwedosi ye-clopidogrel, enokunciphisa umngcipheko obanzi wokuhlaselwa sisifo sentliziyo, ukubetha kunye nokufa ngenxa yesifo sentliziyo ngama-20%, kwaye inesiphumo esikhawulezayo. , isiphumo esihle sokunyanga, ukunganyangeki kakuhle kweziyobisi kunye ne-bioavailability, kunye netyhefu ephantsi.