Ihoyilesi eshushu ethengisayo Ibrutinib Intermediates N-3 CAS 330792-70-6

Sinale motto engqondweni, ngoku siye sajika sibe phakathi kwabona benzi bobuchule bokuvelisa izinto ezintsha, obunexabiso eliphezulu, kunye namaxabiso akhuphisanayo kwi-Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Sijonge phambili ukubonelela ngeemveliso zethu kwixesha elizayo elingekude, kwaye uya kufumana ikowuti yethu isengqiqweni kwaye umgangatho weemveliso zethu ugqwese kakhulu!
Sinale motto engqondweni, ngoku siye sabonakala siphakathi kwabona benzi bobuchule bunokuthi gqi, bonexabiso, nabakhuphisana ngamaxabiso ezinto.I-China Ibrutinib N-3 kunye nabaPhakathi, Ukuza kuthi ga ngoku iimveliso zethu zithunyelwe empuma Yurophu, kuMbindi Mpuma, eMzantsi-mpuma, eAfrika naseMzantsi Melika njl.Sihlonipha inqununu yethu engundoqo yokunyaniseka kwishishini, eyona nto iphambili kwinkonzo kwaye siya kwenza konke okusemandleni ethu ukubonelela abathengi bethu ngeemveliso ezikumgangatho ophezulu kunye nenkonzo ebalaseleyo.

Iphakathi kwi-synthesis ye-allopurinol.

Ngomnye we-3-amino-4-substituted pyrazole series.Ingasetyenziswa njengendawo ephakathi ukudibanisa iikhompawundi ezininzi ze-pharmacologically ezisebenzayo ze-organic, ezifana ne-allopurinol, enye ye-pyrazolopyrimidine derivatives series, le yokugqibela ukususela ngo-1963 Ukususela ekusetyenzisweni kwayo kwezonyango, iye yaba iyeza eliphambili lokunyanga i-gout.Okwangoku, zimbalwa iindlela ezaziwayo zokudibanisa

I-3-aminopyrazole-4-carboxamide hemisulfate e-China, ngokukodwa ngokuphendula i-malononitrile kunye ne-triethyl orthoformate ukulungiselela i-ethoxymethylene malononitrile, kwaye emva koko kunye ne-Reactivity ye-hydrazine hydrate ivelisa i-3-amino-4-cyanopyrazole, ekugqibeleni isabela nge-asidi egxininisiweyo yokuvelisa i-sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), isivuno siphelele i-synthesis ngale ndlela malunga ne-60% (ibalwa njenge-malononitrile), le ndlela Ibandakanya ukuphendulwa kwamanyathelo amathathu, amanyathelo amade, kunye ne-reagents esetyenzisiweyo, njenge-malononitrile kunye ne-ethoxymethylene malononitrile, inetyhefu kwaye iyabiza.Ukongezelela, i-3-aminopyrazole-4 elungiselelwe yile ndlela -I-Formamide hemisulfate inombala onzima ukuwususa kwaye ufuna ukuqhutyelwa okongezelelweyo, okunzima kakhulu.

Kukho iingxelo kwiincwadi zangaphandle zisebenzisa i-pyridylamide hydrazone kunye ne-ethoxymethylene malononitrile njengezinto ezibonakalayo zokufumana i-3-amino-4-cyanopyrazole ngokudibanisa kunye ne-cyclization, kwaye emva koko uphendule nge-acid egxininisiweyo ye-sulfuric ukufumana i-compound ekujoliswe kuyo (Reuken G Jones. i-activemethylene compounds [J] J Am Chem Soc. 1952,74 (5): 4889 4891).Izinto eziphambili ezisetyenziswa kule ndlela ziyabiza, isivuno sokusabela asiphezulu, kwaye inzuzo yemveliso yoshishino iphantsi.Kumele ukuba kunzima.

Umgangatho wesiGqeba:Umgangatho woShishino
Umphandle:Umgubo omhlophe okanye omthubi

Umqulu:25kg/igubu
uvavanyo (HPLC) umxholo Omkhulu kuno okanye ulingana no 98.0%
ubumsulwa (HPLC) umxholo Omkhulu kuno okanye ulingana ne 99.5%

JIN DUN Medical uyeIsiqinisekiso se-ISO kwaye sidibana nemigangatho yemveliso ye-GMP, kuqeshwe iingcali zasekhaya nezangaphandle zokwenziwa kweziyobisi ezinamava atyebileyo ukukhokela iR&D yenkampani.

I-TECHNOL OGY I-ADVANTAGES
●Uxinzelelo oluPhezulu lweCatalytic Hydrogenation.Uxinzelelo oluPhezulu lwe-Hydrogenolysis Reaction.I-Cryogenic Reaction (<-78%C)
● I-Aromatic Heterocyclic Synthesis
● Ukusabela ngokutsha
● IsiGqibo seChiral
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction

Izixhobo

ILebhu yethu inezixhobo ezahlukeneyo zovavanyo kunye novavanyo, ezinjenge: NMR (Bruker 400M), HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, iKhalorimitha yokuSkena okwahlukileyo (DSC), iMicroscope ye-Electron...

R&D Iqela

I-Jindun Medical ineqela labasebenzi abaqeqeshiweyo be-R&D, kwaye iqeshe iingcali ezininzi zokwenziwa kweziyobisi zasekhaya nezangaphandle ukukhokela i-R&D, ukwenza udibaniso lwethu luchaneke ngakumbi kwaye lusebenze kakuhle.

Siye sanceda iinkampani ezininzi eziphezulu zamachiza zasekhaya, ezifanaHansoh, Hengrui kunye ne-HEC Pharm.Apha siza kubonisa inxalenye yazo.

Customization Case One:

Inombolo yeCas: 110351-94-5

Ityala leSibini:

Inombolo yeCas: 144848-24-8

Customization Case Three:

Inombolo yeCas: 200636-54-0

1.Lungiselela abaPhakathi abatsha okanye ii-APIs.Ngokufanayo nokwabelana ngetyala elingasentla, abathengi baneemfuno ze-Intermediates ezithile okanye ii-APIs, kwaye abanakuzifumana iimveliso ezifunekayo kwimarike, ngoko sinokunceda ukwenza ngokwezifiso.

2.Ukuphuculwa kweNkqubo yeeMveliso eziDala.Iqela lethu liya kunceda ukukhulisa nokuphucula imveliso enjalo indlela yokusabela indala, ixabiso lemveliso liphezulu, kwaye ukusebenza kakuhle kuphantsi.Sinokubonelela ngamaxwebhu apheleleyo okuhanjiswa kwetekhnoloji kunye nokuphuculwa kwenkqubo, sincede umthengi kwimveliso esebenzayo.

Ukusuka ekujoliswe kuko ngamachiza ukuya kwi-INDs, iJIN DUN Medical ikubonelelaisitophu esinye sezisombululo ze-R&D ezenzelwe wena.

I-JIN DUN Medical igxininisa ekudaleni iqela elinamaphupha, ukwenza iimveliso ezinesidima, ubuqili, ubukhali, kwaye uphume konke ukuze ube liqabane elithembekileyo kunye nomhlobo wabathengi!

Sinale motto engqondweni, ngoku siye sajika sibe phakathi kwabona benzi bobuchule bokuvelisa izinto ezintsha, obunexabiso eliphezulu, kunye namaxabiso akhuphisanayo kwi-Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Sijonge phambili ukubonelela ngeemveliso zethu kwixesha elizayo elingekude, kwaye uya kufumana ikowuti yethu isengqiqweni kwaye umgangatho weemveliso zethu ugqwese kakhulu!
IhoyilesiI-China Ibrutinib N-3 kunye nabaPhakathi, Ukuza kuthi ga ngoku iimveliso zethu zithunyelwe empuma Yurophu, kuMbindi Mpuma, eMzantsi-mpuma, eAfrika naseMzantsi Melika njl.Sihlonipha inqununu yethu engundoqo yokunyaniseka kwishishini, eyona nto iphambili kwinkonzo kwaye siya kwenza konke okusemandleni ethu ukubonelela abathengi bethu ngeemveliso ezikumgangatho ophezulu kunye nenkonzo ebalaseleyo.