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Uluhlu lwamaxabiso kuMgangatho oPhezulu we-Antiviral Entecavir Powder CAS 142217-69-4 ngeXabiso eliPhezulu

Uluhlu lwamaxabiso kuMgangatho oPhezulu we-Entecavir Powder ye-Antiviral CAS 142217-69-4 enoMfanekiso weXabiso eliBonelekileyo
  • Uluhlu lwamaxabiso kuMgangatho oPhezulu we-Antiviral Entecavir Powder CAS 142217-69-4 ngeXabiso eliPhezulu

Uluhlu lwamaxabiso kuMgangatho oPhezulu we-Antiviral Entecavir Powder CAS 142217-69-4 ngeXabiso eliPhezulu

Inkcazelo emfutshane:


Iinkcukacha zeMveliso

Iithegi zeMveliso

Sikwabonisa imveliso okanye inkonzo yokukhangela kunye neenkampani zokuqinisa inqwelomoya.Sineyunithi yethu yokuvelisa kunye neofisi yokukhangela.Singakunika ngokulula phantse zonke iintlobo zentengiso ezifana neentlobo zemveliso yethu yexabiso lexabiso loMgangatho oPhezulu we-Antiviral Entecavir Powder CAS 142217-69-4 ngeXabiso eliBonelekileyo, siya kuqhubeka sizabalazela ukwandisa inkampani yethu kwaye sinikezele ngeemveliso ezisemgangathweni. ngoluhlu lwamaxabiso olunobundlobongela.Nawuphi na umbuzo okanye izimvo zixatyiswa kakhulu.Khumbula ukusibamba ngokukhululekileyo.
Sikwabonisa imveliso okanye inkonzo yokukhangela kunye neenkampani zokuqinisa inqwelomoya.Sineyunithi yethu yokuvelisa kunye neofisi yokukhangela.Singakubonelela ngokulula malunga nalo lonke uhlobo lwentengiso efana neentlobo zemveliso yethuI-China Entecavir kunye ne-142217-69-4, Samkela ngokufudumeleyo abathengi basekhaya nabaphesheya ukuba bandwendwele inkampani yethu kwaye babe nengxoxo yeshishini.Inkampani yethu ihlala igxininisa kumgaqo "womgangatho olungileyo, ixabiso elifanelekileyo, inkonzo yodidi lokuqala".Sizimisele ukwakha ixesha elide, intsebenziswano enobuhlobo kunye nenzuzo ngokufanayo nawe.

Entecavir (SQ 34676;I-BMS 200475) yi-HBV Inhibitor ekhethiweyo kwaye esebenzayo.Kwiiseli ze-HepG2 ixabiso le-EC50 yi-3.75 nM.Amachiza amva nje e-anti-hepatitis B kunye ne-anti-AIDS kwinqanaba lokuqala.

Isiphumo se-Entecavir

Le mveliso i-guanine nucleoside analog, enempembelelo yokuthintela kwi-virus ye-hepatitis B (HBV) polymerase.Inokuthi i-phosphorylated ibe yi-triphosphate esebenzayo, kunye nesiqingatha sobomi be-triphosphate kwiseli yiyure ezili-15.Ngokukhuphisana ne-HBV polymerase yendalo ye-substrate i-deoxyguanosine triphosphate, i-entecavir triphosphate inokuthintela yonke imisebenzi emithathu ye-polymerase ye-viral (reverse transcriptase): (1) i-HBV polymerase initiation;(2) i-pregenomic mRNA Ukuqulunqwa komtya ombi wokuguqulela umva;(3) Ukwenziwa komcu ovumayo we-HBV DNA.I-inhibitory constant (Ki) ye-entecavir triphosphate kwi-HBV DNA polymerase yi-0.0012μM.I-Entecavir triphosphate ine-inhibitory effect ebuthakathaka kwi-cell α, β, δ DNA polymerase kunye ne-mitochondrial γ DNA polymerase, kunye nexabiso le-Ki le-18 ukuya kwi-160 μM.

Chaza

 Entecavir (SQ 34676;I-BMS 200475) iyakhetha kwaye iyasebenza i-HBV Inhibitor.Kwi-HepG2 iiseli EC50 ixabiso yi-3.75 nM.

Eyeleleneyoiindidi

 indlela yomqondiso >> Anti-intsholongwane >> Iindawo zophando HBV >> Yosulela

Ekujoliswe kuko

 EC50: 3.75 nM (anti-HBV, HepG2 iseli)[2]

I-In vitroizifundo

 I-EC50 ye-BMS-200475 ukuya kwi-HBV yi-3.75 nM.Ifakwe kwi-HBV protein primers, kwaye emva koko inyathelo lokuqala le-reverse transcriptase liyathintelwa.Umsebenzi we-antiviral we-BMS-200475 usezantsi kakhulu kunezinye iintsholongwane ze-RNA kunye ne-DNA [1].Xa kuthelekiswa namanye ama-analogs e-deoxyguanosine (i-penciclovir, i-ganciclovir, i-lobulavir kunye ne-acyclovir) okanye i-lamivudine, i-entecavir inokuthi ibe yi-phosphorylated kwi-metabolite yayo esebenzayo.I-intracellular half-life of Entecavir yi-15 iiyure [2].

Kwi-vivouphando

 I-BMS-200475 iphathwa ngomlomo imihla ngemihla kunye ne-dose ukusuka kwi-0.02 ukuya kwi-0.5 mg / kg ubunzima bomzimba kwi-1 ukuya kwiinyanga ze-3, ezinokunciphisa ngokufanelekileyo izinga le-woodchuck hepatitis virus (WHV) viremia kwi-woodchucks enesifo esingapheliyo [3].

Iseliumfuniselo

 I-BMS 200475 ilungiswa nge-phosphate buffered saline (PBS) yaze yaxutywa ngesiphakathi esifanelekileyo esiqulethe i-2% ye-fetus bovine serum.Iiseli ze-HepG2 ze-2.2.15 zifakwe kwi-12-well ye-Biocoat i-collagen-coated plate kubuninzi be-5 × 10 iiseli ze-5 kwiqula ngalinye, kwaye zigcinwe kwindawo edibeneyo iintsuku ezi-2 ukuya kwezi-3, kwaye zigqunywe nge-1 mL ye-BMS 200475. phakathi .Ubalo lwe-HBV lwenziwa ngomhla we-10 [1].

Iimbekiselo

 [1].Innaimo SF, et al.Ukuchongwa kwe-BMS-200475 njenge-inhibitor enamandla kwaye ekhethiweyo ye-virus ye-hepatitis B.Antimicrob Agents Chemother.1997 Jul;41(7):1444-9.[2].Rivkin A, et al.Ukuphononongwa kwe-entecavir kunyango lwe-hepatitis B engapheliyo.Curr Med Res Opin.2005 Nov;21(11):1845-57 [3].Genovesi EV, et al.Ukusebenza kwe-carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 kwimodeli ye-woodchuck ye-virus ye-hepatitis B.Antimicrob Agents Chemother.1998 Dec;42(12):3209-18.

Iimpawu zomzimba kunye neekhemikhali ze-Entecavir

Ukuxinana

 1.8±0.1 g/cm3

Indawo yokubilisa

 734.2ºC ku-760 mmHg

Indawo yokunyibilika

 249-252ºC

Ifomula yemolekyuli

 I-C12H15N5O3

Ubunzima bemolekyuli

 277.279

Indawo yokuflasha

 397.9ºC

Umgangatho ochanekileyo

 277.117493

PSA

 130.05000

LogP

 -0.96

Iimpawu zenkangeleko

 Imhlophe ukuya kumhlophe-mhlophe / umgubo wekristale omthubi

Isalathiso sokuqhafaza

 1.837

Iimeko zokugcina

 -20°C Isikhenkcisi

Entecavir Customs

Ikhowudi yeCustoms 2933990099
Chinese Overview 2933990099. Ezinye iikhompawundi ze-heterocyclic eziqukethe kuphela i-nitrogen heteroatoms.Ixabiso lerhafu eyongeziweyo: 17.0%.Izinga lesaphulelo serhafu: 13.0%.Imiqathango yolawulo: Akukho.Umrhumo wesizwe othandwa kakhulu: 6.5%.Uluhlu lweerhafu ngokubanzi: 20.0%
Iimpawu zesibhengezo Igama lemveliso, umxholo wezithako, ukusetyenziswa, i-hexamethylene chloride, nceda ubonise imbonakalo, i-6-caprolactam, nceda ubonise imbonakalo, umhla wokusayina
Isishwankathelo 2933990090. i-heterocyclic compounds kunye ne-nitrogen hetero-atom (s) kuphela.IVAT:17.0%.Ireyithi yesaphulelo serhafu:13.0%..Intlawulo yeMFN:6.5%.Uluhlu lweerhafu ngokubanzi: 20.0%

Iinkcukacha ezongezelelweyo:

I-Qu Qiang (i-PhD kwi-pharmacology yekliniki, iSebe le-Pharmacy, iSibhedlele sase-Xiangya, iYunivesithi yaseMzantsi Afrika) kunye no-Wang Ruoguang (uGqirha wezoNyango, i-postdoctoral kwi-biology, i-Changsha Ruoguang Medical Research Centre) nayo yabhala ukuba: kwi-regimen ye-entecavir, i-entecavir inokuthathwa. iminyaka emininzi okanye iminyaka eyi-10.Ngaphezu kweminyaka.Kwaye inokusetyenziswa ngabasetyhini abakhulelweyo, ebonisa ukhuseleko oluhle.

Ukuqwalasela ezi ndlela zaziwayo ze-molecular pharmacological, i-Entecavir ingaba nefuthe elibanzi le-antiviral, elingasebenzi kuphela kwi-HBV.

Sisoloko sisebenzisa i-Entecavir ukunyanga izifo zentsholongwane yokuphefumula kwikliniki, kwaye umphumo uyamangalisa.

Okwangoku, kuhlalutyo lokubuyela emva kwezigulana ezingaphezu kwama-500 ze-COVID19 e-Hubei (indawo), ngumntu omnye kuphela owathatha i-entecavir.Ixesha elimiselweyo lalisekuqaleni kukaJanuwari, kwaye ke iyeza layekwa.

Ngelixa bexhasa abasebenzi bezonyango e-Hubei, abanye oogqirha abasezantsi, okanye amaqela asemngciphekweni omkhulu, ngoku asebenzisa i-Entecavir ukunqanda i-COVID19, akukho meko yosulelo.Abantu ekurhaneleka ukuba bathatha i-entecavir, akukho mntu uqhubele phambili wafunyaniswa ukuba une-COVID19.

Imiba yePatent:

Zimbini iinkqubo, 06 inkqubo kunye 89 inkqubo.Ukuphelelwa kwelungelo lomenzi wenkqubo ye-06 kusekude kakhulu (iphelelwa ngo-2023)!Nangona iindleko zenkqubo ziphantsi, umgangatho ulungile, kwaye abasebenzi banokuba namandla, iingcebiso zomntu: Kwizityalo zemichiza, sebenzisa inkqubo ye-06 ukuba ungabi nekratshi kakhulu;kwiinkampani ezixuba amayeza, musa ukuthatha i-fluke kwaye ungabi yingozi kakhulu.

Kwi-2014, i-Chia Tai Tianqing iphumelele kwiintengiso zonyaka ze-10 yezigidigidi ze-yuan ngokuthembela kumachiza aqhelekileyo afana ne-entecavir, apho i-entecavir ibalwa kwi-20%.

Ekubeni i-entecavir ivunyiwe ukuba ingeniswe kwi-2005, ngaphezu kweenkampani ze-100 zasekhaya zonyango ziye zafaka isicelo sokubhaliswa kwemveliso;phakathi kwabo, iinkampani zokuvelisa ezivunyiweyo ziquka i-Jiangsu Zhengda Tianqing Pharmaceutical (ukulinganisa kokuqala), i-Hainan Zhonghe Pharmaceutical, kunye ne-Fujian Guangxi Pharmaceutical Co., Ltd. I-Shengtang Pharmaceutical, i-Jiangxi Qingfeng Pharmaceutical, i-Suzhou Dawnrays Pharmaceutical Pharmaceutical, i-Shaingchung i-Qingfeng Pharmaceutical, i-Shaingchung. Lukang, Zhejiang Huasheng Biopharmaceutical, Changzhi Sanbao Biochemical.

Pharmaceutical, Anhui Baker Biopharmaceutical, Hunan Concord Pharmaceutical Industry, Beijing Xiehe Pharmaceutical Factory, Beijing Baiao Pharmaceutical, Xinlitai Pharmaceutical, Dongyangguang, njl.;ukusuka kumhla wekhontrakthi, le mveliso ingene kwiintlobo zeentlobo ezidumileyo ezichazwe ukususela ngo-2007.

Sikwabonisa imveliso okanye inkonzo yokukhangela kunye neenkampani zokuqinisa inqwelomoya.Sineyunithi yethu yokuvelisa kunye neofisi yokukhangela.Singakunika ngokulula phantse zonke iintlobo zentengiso ezifana neentlobo zemveliso yethu yexabiso lexabiso loMgangatho oPhezulu we-Antiviral Entecavir Powder CAS 142217-69-4 ngeXabiso eliBonelekileyo, siya kuqhubeka sizabalazela ukwandisa inkampani yethu kwaye sinikezele ngeemveliso ezisemgangathweni. ngoluhlu lwamaxabiso olunobundlobongela.Nawuphi na umbuzo okanye izimvo zixatyiswa kakhulu.Khumbula ukusibamba ngokukhululekileyo.
Uluhlu lwexabisoI-China Entecavir kunye ne-142217-69-4, Samkela ngokufudumeleyo abathengi basekhaya nabaphesheya ukuba bandwendwele inkampani yethu kwaye babe nengxoxo yeshishini.Inkampani yethu ihlala igxininisa kumgaqo "womgangatho olungileyo, ixabiso elifanelekileyo, inkonzo yodidi lokuqala".Sizimisele ukwakha ixesha elide, intsebenziswano enobuhlobo kunye nenzuzo ngokufanayo nawe.

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