1.I-Shanghai isungule amayeza e-patent yaseTshayina kunye namalungiselelo alula kunye nonyango olungelulo machiza ukunceda abantu ukulwa nomkhuhlane wasentwasahlobo.
Ulawulo lukaMasipala waseShanghai lweTraditional Medicine yaseTshayina ludize ngomhla wesi-5 ukuba iSiseko seSizwe soThintelo kunye noLawulo lweZifo zeNtsholongwane yezoNyango zaseTshayina (iShanghai) yathatha inkqenkqeza phambili ekuqulunqeni iSicwangciso soThintelo lweMicimbi yaseTshayina kunye neSicwangciso soLawulo lwe-Spring Influenza ka-2023 eShanghai (Uvavanyo) (emva koku kubhekiselwa kuyo njengesicwangciso), ucebise ukuqonda amayeza aseTshayina kumkhuhlane, aqulunqa imimiselo yamayeza aseTshayina kubantu abadala nabantwana ngokusekwe kulwahlulo lwesifo, kwaye usungule amayeza amaninzi emveli anelungelo elilodwa lomenzi wechiza kunye namalungiselelo alula kunye nonyango olungelulo lwechiza lothintelo kunye nolawulo lomkhuhlane. .
Ebusika nasentwasahlobo, imozulu ishushu kwaye iyabanda, umahluko weqondo lobushushu phakathi kwemini nobusuku uyaguquguquka, kwaye izifo ezosulelayo zonyaka ziye zangena kwixesha eliphezulu lesifo.Kutshanje, inani labaguli abanomkhuhlane A kunye nezinye izifo ezifunyenwe kwizibhedlele ezikhulu zaseShanghai liye landa.Isicwangciso sijolise ekunikezeni umdlalo opheleleyo kwiimpawu kunye neenzuzo zamayeza emveli aseTshayina ekuthinteleni kunye nonyango lomkhuhlane.
UZhang Wei, omnye wababhali besi sicwangciso, isekela lenkokeli yeQela leeNgcali ze-COVID-19 kuNyango lweSintu saseTshayina kunye nomlawuli weSebe leSifo sePulmonary kwiSibhedlele saseShuguang, ukholelwa ukuba ukuphuhliswa komkhuhlane (umkhuhlane) ubukhulu becala kukuzenzela. ukunciphisa.Abanye abantwana ababuthathaka kunye nabantu abadala abanezifo ezingaphantsi kunokubangela ezinye iingxaki ngenxa yezifo eziphuma ngaphandle, nto leyo igxininise kuthintelo kunye nonyango lwamayeza emveli aseTshayina kunye namayeza asentshona.Uxelele iintatheli ukuba amayeza emveli aseTshayina akholelwa ukuba umkhuhlane ungowodidi olubandayo lwangoku.Ngokokuqonda kwemveli, ukuxilongwa kunye nonyango lusekelwe ikakhulu kwinkqubo yokwahlulahlula kwe-syndrome kunye neendlela zonyango ze-meridians ezintandathu, ukuhlukana kwe-syndrome ye-Weiqi kunye ne-Yingxue, kunye ne-syndrome ye-syndrome kunye nendlela yonyango ye-jiao emithathu, kunye nengqalelo. ihlawulwa kwisicelo esidibeneyo sokuqinisa kunye nokuphelisa izinto ze-pathogenic ngezigaba kunye nezigaba.
"Umkhuhlane ubukhulu becala uyazenzela kwaye unokunyangeka ngexesha elifutshane emva konyango oluneempawu ngokubanzi kunye nongenelelo lwe-TCM."UZhang Wei wabonisa ukuba, ngaphezu kwamayeza e-patent yaseTshayina kunye namalungiselelo alula acetyiswayo kwisikimu, izibhedlele ezinkulu ze-TCM e-Shanghai zinamava atyebileyo ekuxilongweni kunye nonyango lwe-influenza, kunye noluhlu lwamalungiselelo esibhedlele kunye nemimiselo.
Kuxelwe ukuba usasazo lwamva nje luyi-H1N1.Xa kuthelekiswa nengqele eqhelekileyo, iyosulela kakhulu, inobushushu obuphakamileyo kwaye ihlala ixesha elide, ineempawu ezicacileyo zenkqubo, kwaye ithatha ixesha elide lokugula.
UXue Zheng, umbhali weNkqubo yaBantwana kunye nomlawuli weSebe leZibhedlele zaBantwana kwiSibhedlele sikaMasipala waseShanghai seSintu saseTshayina, ukholelwa ukuba abantwana abangaphantsi kweminyaka emi-5 ubudala banokungenwa ngumkhuhlane.Abantwana basesichengeni somkhuhlane kwaye baneempawu ezinzima ngenxa yemiphunga yabo eethe-ethe.Iyeza lemveli laseTshayina lidlala indima entle kakhulu ekuthinteleni nasekunyangelweni komkhuhlane ebantwaneni, ngakumbi kunyango lwe-influenza A, enokuthintela ukusasazeka kunye nobunzulu bentsholongwane, iphucule ngokukhawuleza iimpawu, kwaye inobubanzi obubanzi.Izifo zabantwana kwizibhedlele ezinkulu zaseTshayina nakwizibhedlele zaseNtshona nazo zinamalungiselelo esibhedlele aqolileyo asetyenziswa kakhulu kwiklinikhi.
Isicwangciso siqulunqe ummiselo wesivumelwano samayeza esintu kunye namayeza emveli aseTshayina anelungelo elilodwa lomenzi wechiza kunye namalungiselelo alula onyango lomkhuhlane wabantwana, kwaye licebe nothotho lweendlela ezilula nezingabizi kakhulu zonyango lwangaphandle lwamayeza emveli aseTshayina.Abazali banokwenza ungenelelo lwamayeza emveli aseTshayina ngeendlela zonyango zangaphandle ezinje nge-dietotherapy, i-massage, amanqaku endlebe, isicelo kunye nonyango lwe-pendant yokunceda abantwana baphucule iimpawu ngokukhawuleza kwaye bafumane impilo ngokukhawuleza.
2.Abaphandi bezenzululwazi bafumene uluhlu lwezithako ezichasene ne-hepatoma ezisebenzayo kwisityalo samayeza i-Artemisia annua.
I-Kunming Institute of Botany, Chinese Academy of Sciences, yabhengeza ngomhla wama-21 ukuba iqela lophando lika-Chen Jijun lifumene uthotho lwee-dimers ze-sesquiterpene ezinoveli kunye nomsebenzi ochasene nomhlaza wesibindi kwisityalo samayeza i-Artemisia scoparia.Iziphumo zophando ezifanelekileyo zisanda kupapashwa kwijenali eyaziwayo kumazwe ngamazwe eSignali yoThutho kunye noNyango oluJolisiweyo.
Umhlaza wesibindi lithumba eliyingozi elisongela impilo yabantu.Unyaka ngamnye, inani leemeko ezintsha zomhlaza wesibindi kwihlabathi lidlula i-840000, kwaye inani lokufa okubangelwa ngumhlaza wesibindi lifikelela kwi-780000, ngelixa malunga ne-50% yamatyala amatsha avela e-China.Okwangoku, kukho i-tyrosine kinase inhibitors ezine, i-sorafenib, i-regafinil, i-lovatinib kunye ne-cabotinib, enye i-vascular endothelial growth factor receptor 2 antagonist, i-ramolumab, kunye ne-PD-1 inhibitors, i-navumab kunye ne-pamuzumab, ezisetyenziselwa unyango lwekliniki yomhlaza wesibindi. , kodwa uhlobo lwesakhiwo lulula kwaye kulula ukuvelisa ukuxhathisa kumachiza.
Kwiminyaka yakutshanje, iqela lophando lika-Chen Jijun lizibophelele ekufuneni i-anti-hepatoma lead compounds kunye neziyobisi ezintsha ezinesakhiwo esikhethekileyo kunye nenkqubo yenoveli yezenzo ezivela kwizityalo ze-Artemisia, kwaye uye waseka ngempumelelo indlela yokwahlula ukudibanisa ukuqondwa kolwalathiso lwe-sesquiterpene dimers e-Artemisia. izityalo kunye nokulandelela umsebenzi anti-hepatoma.Olu phononongo lufumene okokuqala ukuba isicatshulwa se-Artemisia annua sinomsebenzi oqinileyo wokuthintela kwiiseli ezintathu ze-hepatoma, kwaye ngokokuqala ngqa, i-36 inoveli sesquiterpene dimers yeentlobo ze-9 zesakhiwo-Artemisia annua A1-A3, B1-B2, C1-C4 , D, E, F1-F15, G1-G8, H kunye nam sahlukaniswa kwindawo esebenzayo ye-Artemisia annua.
Uphononongo olongezelelweyo lubonise ukuba phakathi kweenoveli ezingama-36 ze-sesquiterpene dimers, umsebenzi we-artemisinin G5 kunye ne-G7 wawungowona ungcono, owawulingana neyeza lokuqala lezonyango le-anti-hepatoma i-sorafenib;Ukongeza, i-artemisinin G7 yasezantsi ibonise ukhetho olungcono kunye nokhuseleko kune-sorafenib ye-THLE-2 kwiiseli zesibindi eziqhelekileyo;Kwangaxeshanye, i-artemisinin G7 yasezantsi inokuthintela ukwanda kweeseli ze-HepG2 ngokuthintela ukuhlasela kunye nokufuduka kweeseli ze-hepatoma, ukukhuthaza i-apoptosis kunye nokuthintela umjikelo weseli we-G2/M.
Olu phononongo lutyhile okokuqala uthotho lwee-dimers ze-sesquiterpene kunye ne-skeleton yenoveli kunye nesakhiwo esahlukileyo kwi-Artemisia annua, yatyebisa iintlobo zesakhiwo se-sesquiterpene dimers kwizityalo ze-Artemisia, kwaye ibonelele ngeentlobo zeemolekyuli zabaviwa kunye nesiseko esibalulekileyo se-pharmacological kuphando lwe-anti entsha. -iziyobisi ze-hepatoma.
Ukuza kuthi ga ngoku, iqela lophando likaChen Jijun lizikhethe kwaye lichonge i-122 inoveli ye-sesquiterpenoid dimers kunye nomsebenzi wokulwa ne-hepatoma ukusuka kwi-Artemisia australis, i-Artemisia sinica, i-Artemisia medinalis, i-Artemisia cowtail kunye ne-Artemisia Mongolica, i-accounting ye-52% yenani elipheleleyo le-sequiter exelwe yi-234. Izityalo zeArtemisia ehlabathini.
JinDun Medicalinentsebenziswano yexesha elide yophando lwezenzululwazi kunye neteknoloji yokuxhunyelelwa kwiiyunivesithi zaseTshayina.Ngezixhobo zonyango ezityebileyo zikaJiangsu, inobudlelwane bexesha elide kunye neIndiya, iSoutheast Asia, iSouth Korea, iJapan kunye nezinye iimarike.Ikwabonelela ngeenkonzo zentengiso kunye nentengiso kuyo yonke inkqubo ukusuka phakathi ukuya kwimveliso egqityiweyo ye-API.Sebenzisa izibonelelo eziqokelelweyo zeYangshi Chemical kwichemistry fluorine ukubonelela ngeenkonzo ezizodwa zokwenza imichiza kumaqabane.Ukubonelela ngenkqubo yokuveliswa kwezinto ezintsha kunye neenkonzo zophando lokungcola kubathengi abajoliswe kuyo.
I-JinDun Medical igxininisa ekudaleni iqela elinamaphupha, ukwenza iimveliso ngesidima, ubuqili, ubukhali, kwaye uphume wonke ube liqabane elithembekileyo kunye nomhlobo wabathengi! Ababoneleli besisombululo esisodwa, i-R&D elungiselelweyo kunye neenkonzo zemveliso ezilungiselelwe abaphakathi bamayeza kunye nee-APIs, yobuchwepheshaimveliso yamayeza elungiselelweyo(CMO) kunye nababoneleli ngeenkonzo zeR&D kunye nemveliso (CDMO).
Ixesha lokuposa: Mar-30-2023