Kule veki, ijenali yezifundo eziphezulu zeNdalo ipapashe iphepha lophando kwi-Intanethi liqela likaNjingalwazi uFeng Liang kwiYunivesithi yaseStanford, lityhila ubume kunye nendlela esebenzayo yesithintelo segazi sothutho lwelipid kwiproteni yeMFSD2A.Oku kufunyaniswe kunceda ukuyila amachiza okulawula ukunyanzeliswa komqobo wegazi-ubuchopho.
I-MFSD2A ngumthuthi we-phospholipid ojongene nokuthathwa kwe-docosahexaenoic acid kwingqondo kwiiseli ze-endothelial ezenza umqobo wegazi-ubuchopho.I-Docosahexaenoic acid yaziwa ngcono njenge-DHA, eyimfuneko kuphuhliso kunye nokusebenza kwengqondo.Iinguqu ezichaphazela umsebenzi we-MFSD2A zinokubangela ingxaki yophuhliso ebizwa ngokuba yi-microcephaly syndrome.
Ikhono lokuthutha i-lipid ye-MFSD2A likwathetha ukuba le proteni ihambelana ngokusondeleyo nengqibelelo yesithintelo segazi-ingqondo.Izifundo zangaphambili zifumene ukuba xa umsebenzi wayo uncitshisiwe, umqobo wegazi-ubuchopho uya kuvuza.Ke ngoko, i-MFSD2A ithathwa njengotshintsho oluthembisayo lolawulo xa kuyimfuneko ukuwela umqobo wegazi-ubuchopho ukuhambisa amayeza onyango kwingqondo.
Kolu phononongo, iqela likaNjingalwazi Feng Liang lisebenzise itekhnoloji ye-cryo-electron microscopy ukufumana ulwakhiwo olunesisombululo esiphezulu se-mouse MFSD2A, ityhila isizinda sayo esikhethekileyo se-extracellular kunye ne-substrate ebopha umgodi.
Ukudibanisa uhlalutyo olusebenzayo kunye ne-molecular dynamics simulations, abaphandi baye bachonga iindawo ezigciniweyo zokubopha i-sodium kwisakhiwo se-MFSD2A, ukuveza iindlela ezinokungena ze-lipid zokungena, kunye nokunceda ukuqonda ukuba kutheni utshintsho oluthile lwe-MFSD2A lubangela i-microcephaly syndrome.
Ixesha lokuposa: Sep-01-2021