Ukufika okutsha kwe-4-Biphenylcarboxylic Acid (92-92-2)

Ngolawulo lwethu olubalaseleyo, amandla obuchule obunamandla kunye nenkqubo yokuphatha umgangatho ophezulu ongqongqo, siqhubeka nokubonelela abathengi bethu ngomgangatho olungileyo othembekileyo, amaxabiso okuthengisa afanelekileyo kunye neenkonzo ezigqwesileyo.Sijolise ekubeni ngokuqinisekileyo ube lelinye lawona maqabane akho anoxanduva kwaye ufumane ukwaneliseka kwakho ngokuFika okuNtsha kwe-4-Biphenylcarboxylic Acid (92-92-2), Umgaqo weshishini lethu uhlala unikezela ngemveliso ekumgangatho ophezulu, inkonzo yobuchwephesha, kunye nonxibelelwano olunyanisekileyo. .Wamkelekile bonke abahlobo ukuba bazame ukwenza ubuhlakani beshishini bexesha elide.
Ngolawulo lwethu olubalaseleyo, amandla obuchule obunamandla kunye nenkqubo yokuphatha umgangatho ophezulu ongqongqo, siqhubeka nokubonelela abathengi bethu ngomgangatho olungileyo othembekileyo, amaxabiso okuthengisa afanelekileyo kunye neenkonzo ezigqwesileyo.Sijonge ekubeni lelinye lawona maqabane anoxanduva kwaye sifumane ukwaneliseka kwakhoChina Organic Synthesis Intermediates, Izinto zethu zentengiso zithunyelwa ikakhulu kuMzantsi-mpuma Asia, kuMbindi Mpuma, kuMntla Merika naseYurophu.Umgangatho wethu uqinisekisiwe.Ukuba unomdla kuyo nayiphi na impahla yethu okanye ungathanda ukuxoxa ngomyalelo wesiko, qiniseka ukuba uziva ukhululekile ukuqhagamshelana nathi.Sijonge phambili ekwenzeni ubudlelwane beshishini obuyimpumelelo kunye nabathengi abatsha kwihlabathi liphela kungekudala.

I-2'-hydroxy-3'-nitro-3-biphenylcarboxylic acid isetyenziswe njengendawo ephakathi kwe-Eltrombopag.
I-Eltrombopag, ephuhliswe yi-GlaxoSmithKline (GSK) e-UK kwaye kamva iphuhliswe ngokudibeneyo kunye ne-Novartis eSwitzerland, yeyokuqala kwaye ivunyiwe kuphela i-molecule encinci ye-non peptide TPO receptor agonist emhlabeni.I-Eltrombopag yavunywa yi-US FDA kwi-2008 yonyango lwe-idiopathic thrombocytopenic purpura (ITP), kunye ne-2014 yonyango lwe-anemia ye-aplastic enzima (AA).Ikwalichiza lokuqala elavunywa yi-US FDA kunyango lwe-AA kwiminyaka engama-30 yakutsha nje.
NgoDisemba 2012, i-US FDA ivume i-Eltrombopag yonyango lwe-thrombocytopenia kwizigulane ezine-hepatitis C engapheliyo (CHC), ukwenzela ukuba izigulane ze-hepatitis C ezine-prognosis embi ngenxa yokubala kweplatelet ephantsi inokuqala kwaye igcine unyango oluqhelekileyo lwe-interferon kwizifo zesibindi.NgoFebruwari3, 2014, i-GlaxoSmithKline yabhengeza ukuba i-FDA inike isiqinisekiso sonyango lwe-Eltrombopag kunyango lwe-hemopenia kwizigulane ezine-chemicalbook aplastic anemia (SAA) ezinzima ezingazange ziphendule ngokupheleleyo kwi-immunotherapy.Ngo-Agasti 24, i-2015, i-US FDA ivume i-Eltrombopag yonyango lwe-thrombocytopenia kubantu abadala kunye nabantwana abaneminyaka eyi-1 kunye nangaphezulu kunye ne-immune immune thrombocytopenia (ITP) abangenayo impendulo eyaneleyo kwi-corticosteroids, i-immunoglobulins okanye i-splenectomy.NgoJanuwari4, 2018, i-Eltrombopag yavunywa ukuba ibhalwe e-China kunyango lwe-immune immune thrombocytopenia (ITP).

Ngolawulo lwethu olubalaseleyo, amandla obuchule obunamandla kunye nenkqubo yokuphatha umgangatho ophezulu ongqongqo, siqhubeka nokubonelela abathengi bethu ngomgangatho olungileyo othembekileyo, amaxabiso okuthengisa afanelekileyo kunye neenkonzo ezigqwesileyo.Sijolise ekubeni ngokuqinisekileyo ube lelinye lawona maqabane akho anoxanduva kwaye ufumane ukwaneliseka kwakho ngokuFika okuNtsha kwe-4-Biphenylcarboxylic Acid (92-92-2), Umgaqo weshishini lethu uhlala unikezela ngemveliso ekumgangatho ophezulu, inkonzo yobuchwephesha, kunye nonxibelelwano olunyanisekileyo. .Wamkelekile bonke abahlobo ukuba bazame ukwenza ubuhlakani beshishini bexesha elide.
Ukufika OkutshaChina Organic Synthesis Intermediates, Izinto zethu zentengiso zithunyelwa ikakhulu kuMzantsi-mpuma Asia, kuMbindi Mpuma, kuMntla Merika naseYurophu.Umgangatho wethu uqinisekisiwe.Ukuba unomdla kuyo nayiphi na impahla yethu okanye ungathanda ukuxoxa ngomyalelo wesiko, qiniseka ukuba uziva ukhululekile ukuqhagamshelana nathi.Sijonge phambili ekwenzeni ubudlelwane beshishini obuyimpumelelo kunye nabathengi abatsha kwihlabathi liphela kungekudala.