Guanosine

IGuanosine isetyenziswa njengendawo ephakathi yeValaciclovir.
I-Valacyclovir liyeza le-guanine analogue antiviral.Isetyenziselwa unyango lweklinikhi ye-herpes simplex kunye nosulelo lwe-herpes zoster kwizifo ezithathelwana ngesondo.Le mveliso yi-precursor ye-acyclovir.Ifakwe ngokukhawuleza emva kokulawulwa komlomo kwaye iguqule ngokukhawuleza ibe yi-acyclovir emzimbeni.Impembelelo yayo ye-antiviral idlalwa yi-acyclovir.Emva kokuba i-acyclovir ingene kwiiseli ezinosulelo lwe-herpes, ikhuphisana ne-deoxynucleoside ye-virus thymidine deoxynucleoside kinase okanye i-cell kinase, kwaye ichiza liba ne-phosphorylated kwi-activated acyclic guanosine triphosphate.Njengesubstrate yokuphindaphinda kwentsholongwane, i-acyclovir ikhuphisana ne-deoxyguanine triphosphate ye-virus ye-DNA polymerase, ethintela ukuhlanganiswa kwe-virus ye-DNA kwaye ibonisa isiphumo sokulwa neentsholongwane.Umsebenzi we-antiviral wale mveliso kwi-vivo ungcono kune-acyclovir, kwaye isalathisi sonyango lwe-herpes simplex virus uhlobo I kunye nohlobo lwe-II luyi-42.91% kunye ne-30.13% ephezulu kune-acyclovir ngokulandelanayo.Ikwanazo nefuthe eliphezulu lokunyanga i-varicella zoster virus.