I-4-chloro-n- (4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
I-4-chloro-n- (4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
Isebenza ngokuvuselela i-presynaptic ephakathi ye-alpha 2- receptors.Umphumo wayo we-hypotensive ufana ne-nifedipine, i-calcium antagonist, kunye ne-captopril, i-ACE inhibitor.Ngoxinzelelo lwegazi oluyimfuneko.
Le mveliso kufuneka yamkele umgaqo weyeza lomntu ngamnye.Ngokuqhelekileyo qala kwi-dose ephantsi, oko kukuthi, i-0.2mg, kanye ngosuku, ethathwe ekuseni.Uhlengahlengiso lwedosi kufuneka lwenziwe ngamaxesha eeveki ezintathu de kube kufunyenwe iziphumo ezanelisayo.Umthamo oqhelekileyo ngu-0.2mg kanye, kabini ngosuku (ekuseni nakusihlwa).I-dose ephezulu ngexesha ngalinye ayiyi kudlula i-0.4mg, kwaye i-dose ephezulu yemihla ngemihla ayiyi kudlula i-0.6mg.Kwizigulane ezinobuthakathaka obuncinci okanye obuphakathi, umthamo omnye akufanele udlule i-0.2 mg okanye i-dose yemihla ngemihla ayifanele idlule i-0.4 mg.
Le mveliso i-agonist ye-α2-receptor, eyi-imidazoline ye-antihypertensive drug.Isetyenziselwa ukumodareyitha kunye nobunzima obuphambili kunye noxinzelelo lwegazi oluphezulu.
Ngenxa yokuba inqanda ukukhutshwa kunye nokuhamba kwendlela yesisu, ifanelekile nakwizigulane ezixinzelelekileyo ezinesifo sesilonda.Ukudibanisa eli yeza kunye ne-diuretics kunokuphucula kakhulu ukusebenza kakuhle.Lichiza elinamandla elisembindini le-antihypertensive kunye neyeza lodidi lwesibini lokuthomalalisa uxinzelelo lwegazi.Ilawulwa ikakhulu ekuhlaleni kwi-ophthalmology.Le mveliso inefuthe lokunciphisa uxinzelelo lwe-intraocular, kwaye ayichaphazeli umfundi kunye nokulungiswa kwamehlo.Iyakwazi ukuxinzelela imithambo yegazi kwiliso, ukunciphisa ukuveliswa kwe-humor aqueous, kunye nokufezekisa umphumo wokunciphisa uxinzelelo lwe-intraocular.Iqala ukusebenza emva kwemizuzu eyi-15 emva kokuba iliso lehla kwaye linokugcina umphumo malunga neeyure ze-8.
Umgangatho:EP10
Umxholo wovavanyo:97.5-102.0%
Umphandle:Imhlophe okanye phantse ngelixa ingumgubo
Umqulu:1kg/ibhegi okanye njengoko kufunwa ngabathengi
JIN DUN Medical uyeIsiqinisekiso se-ISO kwaye sidibana nemigangatho yemveliso ye-GMP, kuqeshwe iingcali zasekhaya nezangaphandle zokwenziwa kweziyobisi ezinamava atyebileyo ukukhokela iR&D yenkampani.
I-TECHNOL OGY I-ADVANTAGES
●Uxinzelelo oluPhezulu lweCatalytic Hydrogenation.Uxinzelelo oluPhezulu lwe-Hydrogenolysis Reaction.I-Cryogenic Reaction (<-78%C)
● I-Aromatic Heterocyclic Synthesis
● Ukusabela ngokutsha
● IsiGqibo seChiral
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction
Izixhobo
ILebhu yethu inezixhobo ezahlukeneyo zovavanyo kunye novavanyo, ezifana ne: NMR (Bruker 400M) ,HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, iKhalorimitha yokuSkena okwahlukileyo (DSC), iMicroscope ye-Electron...
R&D Iqela
I-Jindun Medical ineqela labasebenzi abaqeqeshiweyo be-R&D, kwaye iqeshe iingcali ezininzi zokwenziwa kweziyobisi zasekhaya nezangaphandle ukukhokela i-R&D, ukwenza udibaniso lwethu luchaneke ngakumbi kwaye lusebenze kakuhle.
Siye sanceda iinkampani ezininzi eziphezulu zamachiza zasekhaya, ezifanaHansoh, Hengrui kunye ne-HEC Pharm.Apha siza kubonisa inxalenye yazo.
Customization Case One:
Inombolo yeCas: 110351-94-5
Ityala leSibini:
Inombolo yeCas: 144848-24-8
Customization Case Three:
Inombolo yeCas: 200636-54-0
1.Lungiselela abaPhakathi abatsha okanye ii-APIs.Ngokufanayo nokwabelana ngetyala elingasentla, abathengi baneemfuno ze-Intermediates ezithile okanye ii-APIs, kwaye abanakuzifumana iimveliso ezifunekayo kwimarike, ngoko sinokunceda ukwenza ngokwezifiso.
2.Ukuphuculwa kweNkqubo yeeMveliso eziDala.Iqela lethu liya kunceda ukukhulisa nokuphucula imveliso enjalo indlela yokusabela indala, ixabiso lemveliso liphezulu, kwaye ukusebenza kakuhle kuphantsi.Sinokubonelela ngamaxwebhu apheleleyo okuhanjiswa kwetekhnoloji kunye nokuphuculwa kwenkqubo, sincede umthengi kwimveliso esebenzayo.
Ukusuka ekujoliswe kuko ngamachiza ukuya kwi-INDs, iJIN DUN Medical ikubonelelaisitophu esinye sezisombululo ze-R&D ezenzelwe wena.
I-JIN DUN Medical igxininisa ekudaleni iqela elinamaphupha, ukwenza iimveliso ezinesidima, ubuqili, ubukhali, kwaye uphume konke ukuze ube liqabane elithembekileyo kunye nomhlobo wabathengi!
